34 research outputs found
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Computer trading and systemic risk: a nuclear perspective
Financial markets have evolved to become complex adaptive systems highly reliant on the communication speeds and processing power afforded by digital systems. Their failure could cause severe disruption to the provision of financial services and possibly the wider economy. In this study we consider whether a perspective from the nuclear industry can provide additional insights
Prognostic Role of Androgen Receptor in Triple Negative Breast Cancer: A Multi-Institutional Study
Background: Androgen Receptor (AR) has emerged as a potential therapeutic target for AR-positive triple-negative breast cancer (TNBC). However, conflicting reports regarding AR’s prognostic role in TNBC are putting its usefulness in question. Some studies conclude that AR positivity indicates a good prognosis in TNBC whereas others suggest the opposite, and some show that AR status has no significant bearing on the patients’ prognosis. Methods: We evaluated the prognostic value of AR in resected primary tumors from TNBC patients from six international cohorts {US (n=420), UK (n=239), Norway (n=104), Ireland (n=222), Nigeria (n=180), and India (n=242); total n=1407}. All TNBC samples were stained with the same anti-AR antibody using the same immunohistochemistry protocol, and samples with ≥1% of AR-positive nuclei were deemed AR-positive TNBCs. Results: AR status shows population-specific patterns of association with patients’ overall survival after controlling for age, grade, population, and chemotherapy. We found AR-positive status to be a marker of good prognosis in US and Nigerian cohorts, a marker of poor prognosis in Norway, Ireland and Indian cohorts, and neutral in UK cohort. Conclusion: AR status, on its own, is not a reliable prognostic marker. More research to investigate molecular subtype composition among the different cohorts is warranted
An investigation on the optimisation of electrochemicallly pigmented aluminium oxide selective collector coatings
In order to produce selective coatings on aluminium substrates to be used as absorber plates in high efficiency solar collectors, nickel pigmentation has been applied to anodically oxidized surfaces. Optical and structural properties of electrochemically formed aluminium oxide films as function of electrolysis conditions such as, applied current, pH, temperature and concentration of metal ions have been examined using electron spectroscopy and scanning electron microscopy. The optimisation of the absorptivity/emissivity ratio of the surfaces in terms of preparation conditions is described. Nickel pigmentation of porous aluminum surfaces was also investigated as a function of electrochemical pigmentation conditions. Mechanisms contributing to selectivity in anodically produced oxides and electrodeposits are discussed. Copyright © 1996 Published by Elsevier Science Ltd
An investigation on the optimization of electrochemically pigmented aluminum oxide collector coatings
Cataloged from PDF version of article.In order to produce selective coatings on aluminium substrates to be used as absorber plates
in high efficiency solar collectors, nickel pigmentation has been applied to anodically oxidized
surfaces. Optical and structural properties of electrochemically formed aluminium oxide films as
function of electrolysis conditions such as, applied current, pH, temperature and concentration
of metal ions have been examined using electron spectroscopy and scanning electron
microscopy. The optimisation of the absorptivity/emissivity ratio of the surfaces in terms of
preparation conditions is described. Nickel pigmentation of porous aluminum surfaces was also
investigated as a function of electrochemical pigmentation conditions. Mechanisms contributing
to selectivity in anodically produced oxides and electrodeposits are discussed. Copyright © 1996 Published by Elsevier Science Ltd