34 research outputs found

    Prognostic Role of Androgen Receptor in Triple Negative Breast Cancer: A Multi-Institutional Study

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    Background: Androgen Receptor (AR) has emerged as a potential therapeutic target for AR-positive triple-negative breast cancer (TNBC). However, conflicting reports regarding AR’s prognostic role in TNBC are putting its usefulness in question. Some studies conclude that AR positivity indicates a good prognosis in TNBC whereas others suggest the opposite, and some show that AR status has no significant bearing on the patients’ prognosis. Methods: We evaluated the prognostic value of AR in resected primary tumors from TNBC patients from six international cohorts {US (n=420), UK (n=239), Norway (n=104), Ireland (n=222), Nigeria (n=180), and India (n=242); total n=1407}. All TNBC samples were stained with the same anti-AR antibody using the same immunohistochemistry protocol, and samples with ≥1% of AR-positive nuclei were deemed AR-positive TNBCs. Results: AR status shows population-specific patterns of association with patients’ overall survival after controlling for age, grade, population, and chemotherapy. We found AR-positive status to be a marker of good prognosis in US and Nigerian cohorts, a marker of poor prognosis in Norway, Ireland and Indian cohorts, and neutral in UK cohort. Conclusion: AR status, on its own, is not a reliable prognostic marker. More research to investigate molecular subtype composition among the different cohorts is warranted

    An investigation on the optimisation of electrochemicallly pigmented aluminium oxide selective collector coatings

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    In order to produce selective coatings on aluminium substrates to be used as absorber plates in high efficiency solar collectors, nickel pigmentation has been applied to anodically oxidized surfaces. Optical and structural properties of electrochemically formed aluminium oxide films as function of electrolysis conditions such as, applied current, pH, temperature and concentration of metal ions have been examined using electron spectroscopy and scanning electron microscopy. The optimisation of the absorptivity/emissivity ratio of the surfaces in terms of preparation conditions is described. Nickel pigmentation of porous aluminum surfaces was also investigated as a function of electrochemical pigmentation conditions. Mechanisms contributing to selectivity in anodically produced oxides and electrodeposits are discussed. Copyright © 1996 Published by Elsevier Science Ltd

    An investigation on the optimization of electrochemically pigmented aluminum oxide collector coatings

    No full text
    Cataloged from PDF version of article.In order to produce selective coatings on aluminium substrates to be used as absorber plates in high efficiency solar collectors, nickel pigmentation has been applied to anodically oxidized surfaces. Optical and structural properties of electrochemically formed aluminium oxide films as function of electrolysis conditions such as, applied current, pH, temperature and concentration of metal ions have been examined using electron spectroscopy and scanning electron microscopy. The optimisation of the absorptivity/emissivity ratio of the surfaces in terms of preparation conditions is described. Nickel pigmentation of porous aluminum surfaces was also investigated as a function of electrochemical pigmentation conditions. Mechanisms contributing to selectivity in anodically produced oxides and electrodeposits are discussed. Copyright © 1996 Published by Elsevier Science Ltd
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